A cryptic message from the past sends James Bond on a rogue mission to Mexico City and eventually Rome, where he meets Lucia Sciarra [Monica Bellucci], the beautiful and forbidden widow of an infamous criminal. Bond infiltrates a secret meeting and uncovers the existence of the sinister organisation known as SPECTRE.
Meanwhile back in London, Max Denbigh [Andrew Scott], the new head of the Centre for National Security, questions Bond’s actions and challenges the relevance of MI6, led by M [Ralph Fiennes]. Bond covertly enlists Moneypenny [Naomie Harris] and Q [Ben Whishaw] to help him seek out Madeleine Swann [Léa Seydoux], the daughter of his old nemesis Mr. White [Jesper Christensen], who may hold the clue to untangling the web of SPECTRE. As the daughter of an assassin, she understands Bond in a way most others cannot.
As Bond ventures towards the heart of SPECTRE, he learns of a chilling connection between himself and the enemy he seeks, played by Christoph Waltz.